Managing MS Symptoms

Mood Liability / Bipolar Affective Disorder

(see also Depression)

Mood swings alternating between mania and depression, known as bipolar disorder, are more common in MS than in the general population. Studies are small, but estimates suggest it can occur as often as 13% for the MS population as compared to 1% in the population at large. Bipolar disorder may occur as a disease symptom, or may occur in response to drug treatment, most commonly, steroids. Lithium, carbemazepine, and valproate are the most commonly used mood stabilizers, as well as gabapentin and lamotrigine. Data on the use of these drugs in MS is mostly anecdotal and large studies are lacking. Of note, lithium can produce increased urine output and so may be poorly tolerated by people with bladder dysfunction.

Key Healthcare Professionals:
Family doctor, Neurologist, Psychiatrist

Symptom Management:
Screening for additional mental health issues such as depression should be considered.

Other Resources:
Mind Matters: MS can bring changes to mood and memory
MS Society of Canada publication.

An MS Society of Canada website that provides information on a variety of topics. Information is provided by a range of North American experts who respond to inquires from individuals affected by MS.

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